Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization

modification of nanoclay for improving the physico-mechanical properties of dental adhesives

هدف اصلی این مطالعه تهیه یک سامانه نوین چسب عاجی دندانی بر پایه نانورس پیوند شده با پلی متاکریلیک اسید، نانورس پیوند شده با پلی اکریلیک اسید، مخلوط نانوسیلیکا و نانورس پیوند شده با پلی متاکریلیک اسید، مخلوط نانوسیلیکا و نانورس پیوند شده با پلی اکریلیک اسید و نانورس پیوند شده با کیتوسان اصلاح شده با گلایسیدیل متاکریلات است. پیوند پلی متاکریلیک اسید و پلی اکریلیک اسید بر ری سطح نانورس در حضور و ...

Ordering of dipeptide chains on Cu surfaces through 2D cocrystallization.

We report on the induced ordering of dispersed chiral diphenylalanine (Phe-Phe) chains grown on the anisotropic Cu(110) and isotropic Cu(100) surfaces. Scanning tunneling microscopy (STM) data reveal that 2D extended hybrid molecular motifs can be fabricated by utilizing terephthalic acid (TPA) molecules as linkers. These act as a molecular "glue" to bridge the isolated Phe-Phe chains without a...

Cocrystallization in Nutraceuticals

Modifying superoxide dismutase for improved biopharmaceutical properties

The superoxide dismutase enzyme (SOD) contributes to the physiological equilibrium between pro-oxidants and antioxidants, by destroying the superoxide anion (O2). However, its therapeutic use is limited by its fast clearance from the bloodstream and inactivation by its own reaction product, i.e. hydrogen peroxide. Here is a summary of the main strategies developed to circumvent these limitation...

Vinpocetine Monograph

Description Vinpocetine (vinpocetine-ethyl apovincaminate) was synthesized in the late 1960s from the alkaloid vincamine, extracted from the leaf of the lesser periwinkle plant (Vinca minor). Vinpocetine was made available under the trade name Cavinton in 1978 and has since been used widely in Japan, Hungary, Germany, Poland, and Russia for the treatment of cerebrovascular-related pathologies. ...